On a chromosome far, far away Oncogenic translocations Global synthetic lethality
نویسندگان
چکیده
منابع مشابه
Global Linkage Map Connects Meiotic Centromere Function to Chromosome Size in Budding Yeast
Synthetic genetic array (SGA) analysis automates yeast genetics, enabling high-throughput construction of ordered arrays of double mutants. Quantitative colony sizes derived from SGA analysis can be used to measure cellular fitness and score for genetic interactions, such as synthetic lethality. Here we show that SGA colony sizes also can be used to obtain global maps of meiotic recombination b...
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Molecular evidence linking polyoma virus to p53 inactivation is thus far lacking, setting this highly oncogenic virus apart from other DNA tumor viruses. As a biological test for interaction, we studied the effects of p53 loss on development of virus-induced tumors. The absence of p53 led to more rapid tumor development on two different mouse backgrounds, indicating synergism between p53 loss a...
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In their recent editorial, Baltussen and colleagues provide a concise summary of the prevailing discourse on priority-setting in health policy. Their perspective is entirely consistent with current practice, yet they unintentionally demonstrate the narrowness and moral precariousness of that discourse and practice. I respond with demonstrations of the importance of ‘interrogating scarcity’ in a...
متن کاملUsing synthetic lethality and integration of genomic data for finding spindle migration genes
Background: Large scale screens for synthetic lethality are widely used in yeast genetics to systematically search for genes that are involved in specific biological processes. Often the amounts of data resulting from single screens far exceed the capacities of experimental characterization of every target found. Thus, computational tools are required to select promising candidates from a scree...
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تاریخ انتشار 2005